SMART
References Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Schultz et al. (2000) Nucleic Acids Res 28, 231-234
HOME | LITERATURE | ABOUT | GLOSSARY | WHAT'S NEW | FEEDBACK
S imple
M odular
A rchitecture
R esearch
T ool

Domains within the query sequence of 1051 residues


Mouse over domain / undefined region to see the limits; click on it to go to further annotation; right-click to save whole protein as PNG image
Transmembrane segments as predicted by the TMHMM2 program (TRANS), coiled coil regions determined by the Coils2 program (COIL) and Segments of low compositional complexity, determined by the SEG program (SEG)signal peptides determined by the SignalP program (SIGNAL), GPI anchors are indicated by (GPI-anchor). Hits only found by BLAST are indicated by  for hits in the schnipsel database and  for hits against PDB. Regions containing repeats detected by Prospero, but not covered by domains are indicated by 
 
 

Architecture analysis

Display all proteins with similar domain organisation.
Display all proteins with similar domain composition.


The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are marked 'hidden'

Confidently predicted domains, repeats, motifs and features:

name begin end E-value
signal peptide 1 22 -
low complexity 29 92 -
transmembrane 108 130 -
low complexity 143 154 -
low complexity 159 170 -
low complexity 180 190 -
low complexity 278 301 -
low complexity 334 349 -
low complexity 401 410 -
low complexity 427 444 -
low complexity 458 473 -
low complexity 484 506 -
low complexity 526 537 -
FH2 588 999 5.21e-163
low complexity 1027 1039 -


These feature and domains are not shown in the diagram, either because their scores are less significant than the required threshold, or because they overlap with some other source of annotation:
name begin end E-value reason
low complexity 2 20 - overlap
low complexity 108 129 - overlap
Pfam:FH2 588 999 1.10e-109 overlap
Pfam:SRP54 680 693 5.00e+00 overlap
coiled coil 757 789 - overlap
low complexity 814 825 - overlap



Summary of BLAST results. Note that the probabilities are not directly comparable to those in the table above.

name seq begin end E-value
Blast:FH2 Q9SE97 588-999 588 999 0.00e+00



Bork GroupBiocomputing UnitEMBL HomeMRC FGU