RPS-BLAST 2.2.1 [Apr-13-2001]

Query= Bprotein gi|2194126|gb|AAB61101.1| EST gb|T43335 comes
from this gene. [Arabidopsis thaliana]
         (760 letters)
PSSMs producing significant alignments: Score
(bits)		 E
value
 
gnl|Smart|smart00498 FH2, Formin Homology 2 Domain; FH proteins control rearrangeme... 339 3e-94
gnl|Pfam|pfam02181 FH2, Formin Homology 2 Domain 315 7e-87

gnl|Smart|smart00498, FH2, Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.
query to multiple alignment, display   sequences
             CD-Length = 445 residues,  99.8% aligned
             Score =  339 bits (870), Expect = 3e-94
Query:  297  GGETSKQVKLKPLHWDKVNPDSDH-SMVWDKIDRGSF--SFDGDLMEALFGYVAVGK---  350
Sbjct:  2    KKEPKPKKKLKPLHWDKLNPDDKSRGTVWDELDENKLYNNLDLDELEELFAAKEKTKSAK  61

Query:  351  KSPEQGDE--KNPKSTQIFILDPRKSQNTAIVLKSLGMTREELVESLIEGNDFV--PDTL  406
Sbjct:  62   KDLSEKKSVLKKKVKQNFKILDPKRSQNLAILLRSLDLSYEEIKVAILEGDEKVLSEDLL  121

Query:  407  ERLARIAPTKEEQSAILEFDGDTA-KLADAETFLFHLLKSVPTAFTRLNAFLFRANYYPE  465
Sbjct:  122  EQLLKFAPTEEELKKLREYKEDDPEELARAEQFLLLLSN-IPYLEERLNALLFKSNFEEE  180

Query:  466  MAHHSKCLQTLDLACKELRSRGLFVKLLEAILKAGNRMNAGTARGNAQAFNLTALLKLSD  525
Sbjct:  181  VEDLKPKLRKVEAASEELRESKKFRKLLELILAIGNYMNGGTRRGQAQGFKLSSLLKLSD  240

Query:  526  VKSVDGKTSLLNFVVEEVVRSEGKRCVMNRRSHSLTRSGSSNYNGGNSSLQVMSKEEQEK  585
Sbjct:  241  VKSADNKTTLLHFLVKIIRKKYPDLLDFYSDLHHLDKASKVNLEQLEKDVKSLERQIKNL  300

Query:  586  EYLKLGLPVVGGLSSEFSNV----KKAACVDYETVVATCSALAVRAKDAKTVIGECEDGE  641
Sbjct:  301  ELDLGGLSDPEGHPDKFLEVMTPFLKAAKEDYDKLQKDLRDMKTLFENLVEYYGEDPKDV  360

Query:  642  G-----GRFVKTMMTFLDSVEEEVKIAKGEERKVMELVKRTTDYYQAGAVTKGKNPLHLF  696
Sbjct:  361  SPEEFFKDFNEFLEEFKKAAEENRKEKEEEERRRRQLAKETTEYEQLSSKQKERNPLRDF  420

Query:  697  VIVRDFLAMVDKVCLDIMRNMQRRK  721
Sbjct:  421  EISRDFLGVLDSLLKELDTDSSFRR  445
gnl|Pfam|pfam02181, FH2, Formin Homology 2 Domain.
query to multiple alignment, display   sequences
             CD-Length = 445 residues,  99.8% aligned
             Score =  315 bits (806), Expect = 7e-87
Query:  297  GGETSKQVKLKPLHWDKVNPDSDH-SMVWDKIDRGSFSFDGDL--MEALFGYVAVGKKSP  353
Sbjct:  2    KKPPKPKKPLKQLHWTKLNPSEKSKGTFWDELDETKLTNEGDLDELEELFKTKEPTKSAK  61

Query:  354  EQGDE-----KNPKSTQIFILDPRKSQNTAIVLKSLGMTREELVESLIEGNDFV--PDTL  406
Sbjct:  62   KGVSETKSLMKKKVKQNLKILDPKRSQNLEILLRKLDMSFEEIKVAILEVDEKVLNVDLL  121

Query:  407  ERLARIAPTKEEQSAILEFDGDTAKLADAETFLFHLLKSVPTAFTRLNAFLFRANYYPEM  466
Sbjct:  122  EQLLKFAPTKEELDKLREVKEDPEELSRAEQFLLLLSN-IPYLEERLNALLFKLNFEEEV  180

Query:  467  AHHSKCLQTLDLACKELRSRGLFVKLLEAILKAGNRMNAGTARGNAQAFNLTALLKLSDV  526
Sbjct:  181  EDLKPQLEKVTAASEELRESKKFKKLLELILAIGNYMNGGSRRGQAKGFKLSSLTKLLDT  240

Query:  527  KSVDGKTSLLNFVVEEVVRSEGKRCVMNRRSHSLTRSGSSNYNGGNSSLQVMSKEEQEKE  586
Sbjct:  241  KSADNKTTLLHYIVKIIRKKYPELLDFYSDLHHVDEASKVNLEELEKDVKSLERQIKNLE  300

Query:  587  YLKLGLPVVGGLSSEFSNV----KKAACVDYETVVATCSALAVRAKDAKTVIGE-----C  637
Sbjct:  301  LDLGGLSDPELHPDKFIEVMLPFLKAAKEKFDKLQSDLKDMKTRLESLVRYYGEDPKDLS  360

Query:  638  EDGEGGRFVKTMMTFLDSV-EEEVKIAKGEERKVMELVKRTTDYYQAGAVTKGKNPLHLF  696
Sbjct:  361  PNEFFKDFNEFLKEFSKARKENQRKELEEELRRRRKLAKSLLEREQGKSKQKERNPLMDG  420

Query:  697  VIVRDFLAMVDKVCLDIMRNMQRRK  721
Sbjct:  421  EAELDFKGVLDSLLKALRTDSSSRR  445