CD:

smart00498,   CD-Search result with query-sequence added

Description: FH2, Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.
Source: Smart
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FASTA with gaps
Phylip format
Conservation color threshold: 
Alignment width: 
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
consensus     1 PKKEPKPKKKLKPLHWDKLN---------------------------------------P 21
query       296 sGGETSKQVKLKPLHWDKVN---------------------------------------P 316
gi 6691125  381 EKSEEILKPKLKTLHWDKVR---------------------------------------A 401
gi 6041849  469 EGTTDRPKPKLKPLPWDKVR---------------------------------------P 489
gi 6225268  748 PKKLYKPEVQLRRPNWSKLV---------------------------------------A 768
gi 544344   759 RKPAIEPSCPMKPLYWTRIQindks----------------------------------- 783
gi 2194126  296 SGGETSKQVKLKPLHWDKVN---------------------------------------P 316
gi 2281090  438 EKKVETMKPKLKTLHWDKVR---------------------------------------A 458
gi 1061334  584 RKSAVNPPKPMRPLYWTRIVtsappaprppsvanstdstensgsspdeppaangadappT 643
gi 5080823  453 GKTEDPTQPKLKPLHWDKMN---------------------------------------P 473
                        70        80        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....|....*....|
consensus    22 DDKSrGTVWDELDENKLyNNLDLDELEELFAAKEKTKSAKKD-LSEKKSVLKKKVKQNFK 80
query       317 DSDH-SMVWDKIDRGSF--SFDGDLMEALFGYVAVGK---KS-PEQGDE--KNPKSTQIF 367
gi 6691125  402 SSdc-eMVWDQLKSSs--fKLNEEMIETLFvvkNPT---LNtsATAKH-FVVSSMSQENR 454
gi 6041849  490 SSrr-tNTWDRLPYNs--sNANSKQr----------------sLSC----DLPMLNQESK 526
gi 6225268  769 EDlsqdCFWTKVKEDrfeNNELFAKLTLTFsaqTKTKKDQEg-GEEKKSVQKKKVKE-LK 826
gi 544344   784 -qdaapTLWDSLEEPh---iRDTSEFEYLFs-kDTTQQKKKp-LSEAYE-KKNKVKKIIK 836
gi 2194126  317 DSdh-sMVWDKIDRGs--fSFDGDLMEALFgyvAVGKKs----PEQGDE--KNPKSTQIF 367
gi 2281090  459 SSsr-vMVWDQIKSNs--fQVNEEMIETLFkvnDPt------sRTRDG--VVQSVSQENR 507
gi 1061334  644 APpatkEIWTEIEETp---lDNIDEFTELF-----SRQAIAp-VSKPKELKVKRAKS-IK 693
gi 5080823  474 DAsr-sMVWHKIDGGs--fNFDGDLMEALFgyvARKPSESNs-VPQNQTVSNSVPHNQTY 529
                       130       140       150       160       170       180
                ....*....|....*....|....*....|....*....|....*....|....*....|
consensus    81 ILDPKRSQNLAILLRSLDLSYEEIKVAILEGDEKVLSEDLLEQLLKFAPTEEELKKLREY 140
query       368 ILDPRKSQNTAIVLKSLGMTREELVESLIEGNDFV--PDTLERLARIAPTKEEQSAILEF 425
gi 6691125  455 VLDPKKSQNIAILLRVLNGTTEEICEAFLEGNAENIGTELLEIllkMAPSKEEERKLKEY 514
gi 6041849  527 VLDPRKSQNVAVLLTTLKLTTNDVCQALRDGHYDALGVELLESlarVAPSEEEEKKLISY 586
gi 6225268  827 VLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNlikQMPEPEQLKMLSEL 886
gi 544344   837 LLDGKRSQTVGILISSLHLEMKDIQQAIFTVDDSVVDLETLAAlyeNRAQEDELTKIRKY 896
gi 2194126  368 ILDPRKSQNTAIVLKSLGMTREELVESLIEGN--DFVPDTLERlarIAPTKEEQSAILEF 425
gi 2281090  508 FLDPRKSHNIAILLRALNVTADEVCEALIEGNSDTLGPELLECllkMAPTKEEEDKLKEL 567
gi 1061334  694 VLDPERSRNVGIIWRSLHVPSSEIEHAIYHIDTSVVSLEALQHmsnIQATEDELQRIKEA 753
gi 5080823  530 ILDPRKSQNKAIVLKSLGMTKEEIIDLLTEGH--DAESDTLEKlagIAPTPEEQTEIIDF 587
                       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|
consensus   141 KEDD----PEELARAEQFLLLLSN-IPYLEERLNALLFKSNFEEEVEDLKPKLRKVEAAS 195
query       426 DGDT----A-KLADAETFLFHLLKsVPTAFTRLNAFLFRANYYPEMAHHSKCLQTLDLAC 480
gi 6691125  515 KDDs----PFKLGPAEKFLKAVLD-IPFAFKRIDAMLYISNFDYEVDYLGNSFETLEAAC 569
gi 6041849  587 SDDs----VIKLAPSERFLKELLN-VPFVFKRVDALLSVASFDSKVKHLKRSFSVIQAAC 641
gi 6225268  887 KDE-----YDDLAESEQFGVVMGT-VPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAAC 940
gi 544344   897 YETSkeedLKLLDKPEQFLHELAQ-IPNFAERAQCIIFRAVFSEGITSLHRKVEIVTRAS 955
gi 2194126  426 DGD-----TAKLADAETFLFHLLKsVPTAFTRLNAFLFRANYYPEMAHHSKCLQTLDLAC 480
gi 2281090  568 KDDDdg-sPSKIGPAEKFLKALLN-IPFAFKRIDAMLYIVKFESEIEYLNRSFDTLEAAT 625
gi 1061334  754 AGG-----DIPLDHPEQFLLDISL-ISMASERISCIVFQAEFEESVTLLFRKLETVSQLS 807
gi 5080823  588 DGE-----PMTLAYADSLLFHILKaVPSAFNRFNVMLFKINYGSEVAQQKGSLLTLESAC 642
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
consensus   196 EELRESKKFRKLLELILAIGNYMNGGTRRG-QAQGFKLSSLLKLSDVKSADNKTTLLHFL 254
query       481 KELRSRGLFVKLLEAILKAGNRMNAGTARG-NAQAFNLTALLKLSDVKSVDGKTSLLNFV 539
gi 6691125  570 EELRSSRMFLKLLEAVLKTGNRMNvGTNRg-DAHAFKLDTLLKLVDVKGADGKTTLLHFV 628
gi 6041849  642 EALRNSRMLLRLVGATLEAGMKSg-------NAHDFKLEALLGLVDIKSSDGRTSILDSV 694
gi 6225268  941 EELRKSESFSNLLEITLLVGNYMNaGSRNa-GAFGFNISFLCKLRDTKSTDQKMTLLHFL 999
gi 544344   956 KGLLHMKSVKDILALILAFGNYMNgGNRTrgQADGYSLEILPKLKDVKSRDNGMNLVDYV 1015
gi 2194126  481 KELRSRGLFVKLLEAILKAGNRMNaGTARg-NAQAFNLTALLKLSDVKSVDGKTSLLNFV 539
gi 2281090  626 GELKNTRMFLKLLEAVLKTGNRMNiGTNRg-DAHAFKLDTLLKLVDIKGADGKTTLLHFV 684
gi 1061334  808 QQLIESEDLKLVFSIILTLGNYMNgGNRQrgQADGFNLDILGKLKDVKSKESHTTLLHFI 867
gi 5080823  643 NELRARGLFMKLLEAILKAGNRMNaGTARg-NAQAFNLTALRKLSDVKSVDAKTTLLHFV 701
                       310       320       330       340       350       360
                ....*....|....*....|....*....|....*....|....*....|....*....|
consensus   255 VKIIRKKYPDLLDFYSDLHHLDKAS--KVNLEQLEKDVKSLERQIKNLELDLGGLSDPEG 312
query       540 VEEVVRSEGKRCVMNRRSHSLTRSG--SSNYNGGNSSLQVMSKEEQEKEYLKLGLPVVGG 597
gi 6691125  629 VQEIIKSEGARLSGG------------NQNHQQ------STTND--DAKCKKLGLQVVSN 668
gi 6041849  695 VQKITESEG------------------------------------------IKGLQVVRN 712
gi 6225268 1000 AELCENDYPDVLKFPDELAHVEKAs--RVSAENLQKNLDQMKKQISDVERDVQNFPAATD 1057
gi 544344  1016 VKYYLRYYDQEAG------------------------------------TDKSVFPLP-- 1037
gi 2194126  540 VEEVVRSEGKRCVMNRRSHSLTRSgssNYNGGNSSLQVMSKEEQ--EKEYLKLGLPVVGG 597
gi 2281090  685 VQEIIKFEGARVPFTPSQSHIG-----DNMAEQ------SAFQD--DLELKKLGLQVVSG 731
gi 1061334  868 VRTYIAQRRKE-----------------------------------GVHPLEIRLPIPEP 892
gi 5080823  702 VEEVVRSEGKRAAMNKNMMSSD-----NGSGEN---ADMSREEQ--EIEFIKMGLPIIGG 751
                       370       380       390       400       410       420
                ....*....|....*....|....*....|....*....|....*....|....*....|
consensus   313 HPDKFLEVMTPFLKAAKEDYDKLQKDLRDMKTLFENLVEYYGEDPKD-VSPEEFFKDFNE 371
query       598 LSSEFSNV----KKAACVDYETVVATCSALAVRAKDAKTVIGECEDG-EG-----GRFVK 647
gi 6691125  669 ISSELINV----KKSAAMDSEVLHNDVLKLSKGIQNIAEVVRSIEAV-GLEESSIKRFSE 723
gi 6041849  713 LSSVLNDA----KKSAELDYGVVRMNVSKLYEEVQKISEVLRLCEETgHSEEHQWWKFRE 768
gi 6225268 1058 EKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKK-LSVEEFFMDLHN 1116
gi 544344  1038 EPQDFF-------LASQVKFEDLLKDLRKLKRQLEASEQQMKLVCKE--SPREYLQPFKD 1088
gi 2194126  598 LSSEFSNV----KKAACVDYETVVATCSALAVRAKDAKTVIGE------CEDGEGGRFVK 647
gi 2281090  732 LSSQLINV----KKAAAMDSNSLINETAEIARGIAKVKEVITELK-----QETGVERFLE 782
gi 1061334  893 AD---VER------AAQMDFEEVQQQIFDLNKKFLGCKRTTAKVLAA--SRPEIMEPFKS 941
gi 5080823  752 LSSEFTNV----KKAAGIDYDSFVATTLALGTRVKETKRLLDQ------SKGKEDG-CLT 800
                       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|
consensus   372 FLEEFKKAAEEN--RKEKEEEERRRRQLAKETTEYEQLSSKQKE-----RNPLRDFEISR 424
query       648 TMMTFLDSVEEE--VKIAKGEERKVMELVKRTTDYYQAGAVTKG-----KNPLHLFVIVR 700
gi 6691125  724 SMNRFMKVAEEK--ILRLQAQETLAMSLVKEITEYVHGDSAREE-----AHPFRIFMVVK 776
gi 6041849  769 SVTRFLETAAEE--IKKIEREEGSTLFAVKKITEYFHVDPAKEE-----AQLLKVFVIVR 821
gi 6225268 1117 FRNMFLQAVKENqkRRKTEEKMR-RAKLAKEKAEKERLE-KQQK-----REQLIDMNAEG 1169
gi 544344  1089 KLEEFFKKAKKE--HKMEESHLENAQKSFETTVGYFGMKPKTGEk---eVTPSYVFMVWF 1143
gi 2194126  648 TMMTFLDSVEEE--VKIAKGEERKVMELVKRTTDYYQAGAVTKG-----KNPLHLFVIVR 700
gi 2281090  783 SMNSFLNKGEKE--ITELQSHGDNVMKMVKEVTEYFHGNSe--------THPFRIFAVVR 832
gi 1061334  942 KMEEFVEGADKS--MAKLHQSLDECRDLFLETMRFYHFSPKACTltlaqCTPDQFFEYWT 999
gi 5080823  801 KLRSFFESAEEE--LKVITEEQLRIMELVKKTTNYYQAGALKE------RNLFQLFVIIR 852
                       490       500
                ....*....|....*....|.
consensus   425 DFLGVLDSLLKELDTDSSFRR 445
query       701 DFLAMVDKVCLDIMRNMQRRK 721
gi 6691125  777 DFLMILDCVCKEVGTINERTI 797
gi 6041849  822 DFLKILEGVCKKMEVTSSLA- 841
gi 6225268 1170 DETGVMDSLLEALQSGAAFRR 1190
gi 544344  1144 EFCSDFKTIWKRESKNISKER 1164
gi 2194126  701 DFLAMVDKVCLDIMRNMQRRK 721
gi 2281090  833 DFLTILDQVCKEVGRVNERTV 853
gi 1061334 1000 NFTNDFKDIWKKEITSLLNEL 1020
gi 5080823  853 DFLGMVDNACSEIARNQRKQQ 873